The Impact of Hormones on Aesthetic Outcomes

In aesthetic medicine, we often focus on tools like biostimulators, microneedling, and supplements. But there’s a deeper driver of skin health and treatment success that’s too often overlooked: Hormones.

“We frequently talk about biostimulators, biohacking and anti-ageing supplements, when in fact the most important part of biohacking lies in optimising our hormones to remain at that biological age when everything was working optimally.”

Sex hormones, particularly oestrogen, progesterone and testosterone - play a crucial role in how well the skin regenerates, responds to treatment, and maintains long-term health.

Hormones: The Foundation for Skin Regeneration

“Hormones are like the garden soil, and biostimulators are the seeds. If the soil is rich, the seeds flourish. If it’s depleted - not much grows.”

Hormones influence:

Fibroblast activity (essential for collagen and elastin production).

Skin hydration and thickness.

Cell turnover.

Tissue repair and wound healing.

Without optimal hormonal support, even advanced treatments like PLLA, CaHA and HA-based injectables may deliver limited or delayed results.

What Happens When Hormones Decline?

After menopause or andropause, hormone levels decline - dramatically in the case of oestrogen in women. This isn’t just a surface concern; it affects the dermis, bone density, and healing capacity.

“When estrogen falls, collagen takes a hit - up to 30% lost in just five years.”

How Sex Hormones Support the Skin:

Oestrogen (Estradiol)
Stimulates collagen and hyaluronic acid production, supports skin thickness, elasticity and hydration, and accelerates healing.

Testosterone
Promotes firmness, sebum regulation, hydration and tissue repair. It also contributes to muscle and bone strength.

Progesterone
Supports the skin barrier, calms inflammation, and balances oestrogen. Its decline can lead to increased sensitivity and breakouts, especially in perimenopausal women.

Why the Oestrogen-Skin Link Matters

“Estradiol plays a vital role in maintaining skin health by directly promoting collagen synthesis, skin hydration, and elasticity.”

Declining oestrogen leads to:

Reduced fibroblast activity.

Thinner, drier, more fragile skin.

Slower regeneration post-treatment.

Most women seeking aesthetic treatments fall into the perimenopausal or menopausal group, where hormonal decline is already underway.

“Let’s say you inject PLLA, CaHA, or HA into skin that’s hormonally depleted. It’s like asking a tired crew to build a mansion with no tools or blueprint.”

Beyond the Skin: Systemic Anti-Ageing Benefits

Balanced estradiol supports:

Bone density.

Cardiovascular health.

Cognitive function and memory.

Reduced risk of neurodegenerative disease.

Lower breast cancer risk.

“We’re not just injecting products - we’re creating regenerative environments.”

Why a Holistic Approach Is Essential

“I want you to think about the treatments we give differently. To approach systemic ageing together with skin and facial ageing.”

In Dr Jonck’s practice, hormone optimisation, gut health, nutrition, and lifestyle play just as big a role as aesthetic procedures.

“At the end of the day, our treatments are influenced by our patients’ current state of health. Lifestyle changes make up a big part of my aesthetic consultation - and it really does make a difference.”

Key Takeaways

Hormones are foundational to skin regeneration and vitality.

Biostimulators depend on a healthy internal environment to be effective.

Addressing hormonal balance improves long-term aesthetic outcomes.

True rejuvenation blends science, systems, and self-awareness.

“Great outcomes come from inside and out. So before reaching for the syringe, always ask: is the skin’s internal environment ready to respond?”

As aesthetic medicine moves toward more regenerative, patient-centered care, it’s time to treat the body as a whole. Hormonal health is not a separate concern - it’s the very foundation of aesthetic success.

Let’s personalise your path to regenerative beauty. Reach out to us to get started.